Genome Stability by DNA Polymerase {beta} in Neural Progenitors Contributes to Neuronal Differentiation in Cortical Development

Genome Stability by DNA Polymerase {beta} in Neural Progenitors Contributes to Neuronal Differentiation in Cortical Development

DNA repair is crucial for genome stability in the developing cortex, as somatic de novo mutations cause neurological disorders. However, how DNA repair contributes to neuronal development is largely unknown. To address this issue, we studied the spatiotemporal roles...
Drosophila Nociceptive Sensitization Requires BMP Signaling via the Canonical SMAD Pathway

Drosophila Nociceptive Sensitization Requires BMP Signaling via the Canonical SMAD Pathway

Nociceptive sensitization is a common feature in chronic pain, but its basic cellular mechanisms are only partially understood. The present study used the Drosophila melanogaster model system and a candidate gene approach to identify novel components required for...
Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development

Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development

Proper neural circuit formation requires the precise regulation of neuronal migration, axon guidance, and dendritic arborization. Mutations affecting the function of the transmembrane glycoprotein dystroglycan cause a form of congenital muscular dystrophy that is...
Polysialylation at Early Stages of Oligodendrocyte Differentiation Promotes Myelin Repair

Polysialylation at Early Stages of Oligodendrocyte Differentiation Promotes Myelin Repair

Polysialic acid is a glycan modification of the neural cell adhesion molecule (NCAM) produced by the polysialyltransferases ST8SIA2 and ST8SIA4. Polysialic acid has been detected in multiple sclerosis plaques, but its beneficial or adverse role in remyelination is...
The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk

The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk

During vertebrate eye morphogenesis, a transient fissure forms at its inferior part, known as the optic fissure. This will gradually close, giving rise to a healthy, spherical optic cup. Failure of the optic fissure to close gives rise to an …