For individuals with coexisting obstructive sleep apnea (OSA) and cardiovascular disease, continuous positive airway pressure (CPAP) does not alter renal function, according to a study published online July 25 in the American Journal of Respiratory and Critical Care Medicine.
Kelly A. Loffler, Ph.D., from Flinders University in Daw Park, Australia, and colleagues examined the effects of CPAP on renal function in individuals with coexisting OSA and cardiovascular disease in a substudy of the international Sleep Apnea and Cardiovascular Endpoints trial. Renal function and adverse events were compared between 102 CPAP treated and 98 usual-care treated patients.
The researchers found that after a median period of 4.4 years, the median change in estimated glomerular filtration rate did not differ significantly between the CPAP and usual-care groups. No between-group differences were seen in the end-of-study urinary albumin:creatinine ratio or the occurrence of serious renal or urinary adverse events. The findings were not influenced by the level of CPAP adherence.
Respironics Sleep and Philips Respironics provided funding for the trial.
SAVE – sleep apnea treatment: No cardiovascular benefit